https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48712 Wed 29 Mar 2023 17:13:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43990 Wed 29 Mar 2023 14:36:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43675 P = 0.005), whereas there was no such association between reperfusion and an excellent outcome with any of the CCM criteria (all p > 0.05). Notably, in IVT-LVO cohort, 58.2% of the PIM-DT positive patients achieved an excellent outcome compared with 31.0% in non-mismatch patients following successful recanalization (P = 0.006).]]> Wed 28 Sep 2022 14:35:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53333 1 s and MTT>145%. Delay time (DT) best estimated the infarct core (AUC = 0.74). The optimal core threshold was a DT >1.5 s. The voxel-based analyses indicated CTP was most accurate in the calcarine (Penumbra-AUC = 0.75, Core-AUC = 0.79) and cerebellar regions (Penumbra-AUC = 0.65, Core-AUC = 0.79). For the volume-based analyses, MTT >160% demonstrated best correlation and smallest mean-volume difference between the penumbral estimate and follow-up MRI (R2 = 0.71). MTT >170% resulted in the smallest mean-volume difference between the core estimate and follow-up MRI, but with poor correlation (R2 = 0.11). Conclusion: CTP has promising diagnostic utility in POCI. Accuracy of CTP varies by brain region. Optimal thresholds to define penumbra were DT >1 s and MTT >145%. The optimal threshold for core was a DT >1.5 s. However, CTP core volume estimates should be interpreted with caution.]]> Wed 28 Feb 2024 16:20:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45158 N = 70) who had experienced a stroke between 5 months and 28 years ago were included in the cross-sectional study, along with age-matched controls (N = 70). We measured stress using both the Perceived Stress Scale and biological markers, and resilience using both the Brief Resilience Scale and the Connor-Davidson Resilience Scale. Stroke outcomes were assessed using the Stroke Impact Scale. We found that, compared with age-matched controls, stroke survivors reported greater levels of perceived stress, and lower levels of resilience. In stroke survivors, both perceived stress and resilience were independently associated with stroke outcomes in linear regression models. In particular, these relationships were observed for cognitive outcomes including mood, memory, and communication. The association between stress and stroke outcome did not differ across time post stroke. Given that resilience is a modifiable psychological construct, future research may consider whether strategies directed at enhancing resilience may improve recovery from stroke. Australia and New Zealand Clinical Trials Registry: ACTRN12617000736347.]]> Wed 26 Oct 2022 19:17:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45222 Wed 26 Oct 2022 15:50:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45125 Wed 26 Oct 2022 12:58:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51178 Wed 24 Apr 2024 12:15:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47544 Wed 22 Mar 2023 15:52:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43520 Wed 21 Sep 2022 11:25:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48907 Wed 19 Apr 2023 16:20:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39768 Wed 13 Mar 2024 08:58:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16010 Wed 11 Apr 2018 09:27:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36591 Wed 10 Jun 2020 14:23:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32712 Wed 09 Mar 2022 16:01:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44000 Z = 2.451, P = 0.014). Conclusion: In acute LAO patients, the presence of SMCV– was a sensitive and specific imaging marker for midline shift. SMCV– had supplementary value to baseline ischemic core volume in predicting midline shift.]]> Wed 05 Oct 2022 15:04:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38036 Tue 27 Jul 2021 15:08:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39658 Tue 21 Mar 2023 17:22:55 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43835 Tue 04 Oct 2022 11:32:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37847 Thu 28 Oct 2021 12:36:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36439 Thu 27 Jan 2022 15:55:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38979 4.5 h time window between patient groups who met and did not meet the perfusion imaging trial criteria. Methods: A discrete event simulation (DES) model was developed to simulate the long-term outcome post EVT in patients meeting or not meeting the extended time window clinical trial perfusion imaging criteria at presentation, vs. medical treatment alone (including intravenous thrombolysis). The effectiveness of thrombectomy in patients meeting the landmark trial criteria (DEFUSE 3 and DAWN) was derived from a prospective cohort study of Australian patients who received EVT for ischemic stroke, between 2015 and 2019, in the extended time window (>4.5 h). Results: Endovascular thrombectomy was shown to be a cost-effective treatment for patients satisfying the clinical trial criteria in our prospective cohort [incremental cost-effectiveness ratio (ICER) of $11,608/quality-adjusted life year (QALY) for DEFUSE 3-postive or $34,416/QALY for DAWN-positive]. However, offering EVT to patients outside of clinical trial criteria was associated with reduced benefit (−1.02 QALY for DEFUSE 3; −1.43 QALY for DAWN) and higher long-term patient costs ($8,955 for DEFUSE 3; $9,271 for DAWN), thereby making it unlikely to be cost-effective in Australia. Conclusions: Treating patients not meeting the DAWN or DEFUSE 3 clinical trial criteria in the extended time window for EVT was associated with less gain in QALYs and higher cost. Caution should be exercised when considering this procedure for patients not satisfying the trial perfusion imaging criteria for EVT.]]> Thu 24 Mar 2022 08:55:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51858 Thu 21 Sep 2023 09:41:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44697 Thu 20 Oct 2022 09:51:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52638 Thu 19 Oct 2023 15:12:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38255 Thu 19 Aug 2021 12:14:52 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38503 Thu 18 Nov 2021 09:53:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43334 2, >4, >6, >8, and >10 s) with PH was examined using receiver operating characteristic (ROC) analysis and logistic regression. Results: Of 94 patients, 23 developed PH on follow-up imaging. Receiver operating characteristic analysis revealed that the greatest area under the curve for predicting PH occurred at DT > 4 s (area under the curve, 0.66). At this threshold of > 4 s, DT lesion volume ≥ 30.85 mL optimally predicted PH with 70% sensitivity and 59% specificity. DT > 4 s volume was independently predictive of PH in a multivariate logistic regression model (P < 0.05). Conclusions: DT > 4 s was the parameter most strongly associated with PH. The volume of moderate, not severe, hypo-perfusion on DT is more strongly associated and may allow better prediction of PH after intra-arterial tPA thrombolysis.]]> Thu 15 Sep 2022 15:04:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43333 Thu 15 Sep 2022 14:57:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33725 Thu 13 Jan 2022 10:30:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40631 Thu 11 Aug 2022 09:02:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31270 Thu 09 Dec 2021 11:04:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46655 Mon 28 Nov 2022 17:43:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31141 Mon 26 Nov 2018 11:08:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42344 Mon 22 Aug 2022 13:54:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52319 Mon 22 Apr 2024 14:04:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51794 0.05). Conclusion: Filling defect of the ipsilateral transverse sinus was associated with edema expansion and an unfavorable outcome irrespective of the baseline arterial collateral status in patients with acute LAO, indicating that FDITS may be an important stroke-related prognostic imaging marker.]]> Mon 18 Sep 2023 15:19:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54767 Mon 11 Mar 2024 15:00:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40206 Mon 08 Aug 2022 13:40:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39528 Mon 08 Aug 2022 11:13:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38990 Fri 25 Mar 2022 14:35:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38827 p < 0.047), whereas the measure of executive functioning was uniquely accounted for by the presence of hypertension and angina (all p < 0.032). Increased stroke risk also predicted performance on the cognitive screening test and the measure of executive functioning (all p < 0.002). Conclusions: Our findings indicate that cognitive impairment following a minor stroke or TIA may be attributed to the high prevalence of chronic vascular risk factors in these patients. This highlights the importance of long-term management of vascular risk factors beyond event recovery to reduce the risk of cognitive impairment. Increased stroke risk (i.e., ABCD2 score) was also associated with reduced cognition, suggesting that it may be helpful in signaling the need for further cognitive evaluation and intervention post-event.]]> Fri 20 May 2022 12:40:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42294 Fri 19 Aug 2022 14:58:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42288 Fri 19 Aug 2022 14:58:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47232 Fri 16 Dec 2022 12:08:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41805 Fri 12 Aug 2022 12:31:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41797 5 mL, the AUC was 0.87, 0.81, and 0.66, respectively. Conclusion: Comprehensive CTP analysis increases the detection of posterior fossa lesions compared to NCCT and should be implemented as part of the routine imaging assessment in posterior fossa strokes.]]> Fri 12 Aug 2022 12:24:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41588 Fri 05 Aug 2022 14:52:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49799 Fri 02 Jun 2023 17:06:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53516 Fri 01 Dec 2023 11:06:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33104 Fri 01 Apr 2022 09:29:07 AEDT ]]>